The first time you press the [Connect] button in GP2U you will see the following prompt:
![Skype prompt](/static/images/screenshots/Skype_prompt1.png)
Click on the check box before "Always ask before opening this type of address" to remove the tick and then click Allow:
![Skype prompt](/static/images/screenshots/Skype_prompt2.png)
Next you will see this prompt
![Skype prompt](/static/images/screenshots/Skype_prompt3.png)
Click the check box before "Do not ask me again" to add a tick and then click OK:
![Skype prompt](/static/images/screenshots/Skype_prompt4.png)
The next time you press [Connect] you will not see these prompts. Skype will place the call immediately.